Chapter 6 – Magnetic Nanoparticles in Stimuli-Responsive Drug Delivery Systems

There has been a lot of interest in the design and development of a multifunctional and stimulus-responsive magnetic nanoparticle (MNP)-based drug delivery system for the detection and treatment of cancer. However, stable in vitro and in vivo and in vivo magnetic iron oxide nanoparticles, strong biocompatibility, high loading effectiveness, and regulated drug release are necessary for their efficient absorption into biomedical systems. To get over these difficulties, surface-functionalized magnetic iron oxide nanoparticles were developed utilizing tailored surface ligands. These nanoparticles offer novel implications for MNP-based drug delivery systems in cancer therapy and imaging. Additionally, to improve the efficacy of the MNP-based delivery system, stimuli-responsive ligand synthesis and design have been integrated with the engineering of several physicochemical characteristics into MNPs. This chapter provides a concise summary of recent advances in the design of stimuli-responsive, multifunctional MNP-based drug delivery systems. It begins by presenting various surface ligands that are employed to create various stimuli-responsive MNP-based delivery systems (see below figure). It then goes over a few techniques for creating stimuli-responsive MNP-based delivery systems (see below figure).